The Effects of Trimix on Penis Size

Trimix vial and needles

For over four years now, I have been working on issues of increasing penis size and improving erection quality. I used Trimix for over two years before I found a more permanent way to treat erectile dysfunction. At this time, I have found some definitive answers as to what effects Trimix has on the size of the penis.

Trimix will not permanently increase the size of the erect penis. This injectable prescription drug is an extremely effective short-term treatment for erectile dysfunction. Trimix will increase the penis size in that you will go from flaccid to erect but it does not make the erection bigger than any other firm erection. This drug is not designed to affect penis size, just to provide erections for men with extreme erectile dysfunction.

In this article, we will look into Trimix as used for erectile dysfunction, Trimix compared to other erection quality treatments, the effectiveness of Trimix as part of a penis enlargement program, and what alternatives are out there for penis enlargement.

Trimix for Erectile Dysfunction

First of all, I am not a doctor. Trimix is a prescription medicine that should only be prescribed by your doctor or urologist. I have had experience using Trimix which may be helpful for you but this is not a substitute for the advice and care of a physician. This section is just a basic overview of my experience using Trimix.

Trimix is an injectable drug for the treatment of erectile dysfunction. Trimix is composed of three drugs: alprostadil, phentolamine, and papaverine. The doctor can vary the amounts of the levels of the individual drugs in the prescription. Trimix is made at a compounding pharmacy where they actually compound your individual prescription so you can not just pick it up at your local Walgreens.

Your prescription of Trimix will come in a small vial of liquid. You draw the prescribed amount up into a hypodermic needle and inject it into the penis shaft at the location specified by your doctor. The prescribing doctor will usually do the first shot with you to show you the placement of the shot and check the effectiveness of the injection. But after that, you are usually on your own with the injections.

These injections may sound very painful but it is not as bad as it may sound. In my experience, it was a tolerable inconvenience in order to obtain a firm erection. It was never fun and I was really glad when I found more permanent ways to treat my erectile dysfunction.

How Trimix Works

Trimix work by relaxing the smooth muscle and opening the blood vessels in your penis, causing an erection. Most men will start to see results within five to fifteen minutes. Personally, I found that I achieved a very firm erection about fifteen minutes after injection whether I engaged in sexual activity or not. My erections with Trimix would last 1-2 hours without ejaculation and 1/2 to one hour with ejaculation.

The erections that I achieved with Trimix were of the same size as the erections that I had achieved in life prior to taking Trimix. Later on, I found other ways to increase the size of the penis but Trimix was not effective in doing this.

Trimix has a number of potential side effects. Failure to follow the instructions of your doctor will increase the possibility of these side effects including priapism. This article here has a lot of good information on Trimix. The information given basically matches what my doctor gave me for information.

Trimix in Comparison to Other ED Medication

Trimix is usually prescribed when the major oral PDE5 inhibitors fail to be effective. The four major PDE5 inhibitors are sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), and avanafil (Stendra).  Oral medications are found to be ineffective in about 25-40% of men and are more ineffective in those men that have diabetes.

Positives of Trimix

The injections of Trimix are much more likely to produce an erection sufficient for intercourse than oral medications (source). This can be a big confidence boost for those with erectile dysfunction. I know that when I had erectile dysfunction, it was a big relief knowing that Trimix would work every time I used it.

Trimix takes less time to work than oral medication. It will produce an erection in as little as five minutes. The oral medications can take from half an hour up to a couple of hours to work (source). As far as pure effectiveness goes, Trimix is much better than oral medications.

Negatives of Trimix

Of course with Trimix, you have the inconvenience and pain of the injections. Trimix can be inconvenient to take when you travel as the medication needs to be refrigerated. The biggest issue that I had with Trimix was the timing of taking it. If you waited until you were sure that your partner was interested, you had to leave and go do the injection. If you tried to be proactive and took the injection early, you run the risk of being stuck with an erection with nothing to do with it.

Another negative of Trimix is the frequency of use. It is not recommended that you inject more than one dose per day. You should not use it more than two days in a row or more than three times a week (source).

From my personal experience, I would have preferred the oral medication if it had worked for me. Since the oral medication did not work, I am glad that I had the Trimix to fall back on. Of course, the best possible outcome is to regain the ability your ability to achieve erections without medication.

It is important to remember that neither the oral medications nor the Trimix will cure erectile dysfunction. If you are looking for a long-term solution, I would suggest some type of acoustic wave treatment program (see below for more details).

Trimix as Part of a Penis Enlargement Program

Trimix is not an effective component of a penis enlargement program. The most important part of a penis enlargement program is to have frequent and firm erections to cement gains made through the use of traction devices or other enlargement techniques. You can not use Trimix often enough to safely have the erections that you need to successfully accompany the penis enlargement program.

If you are at the point where you need to use Trimix to achieve firm erections, you should concentrate on improving your erection quality before starting an enlargement program. I can not stress enough that the key to penis enlargement is these natural erections that occur regularly through the night. Unfortunately, Trimix will not give you these erections so be sure to check out the end of this article or What Works for Erection Quality to find out some long-term solutions for this.

Alternatives for Erection Quality

I have found that the most effective treatment for erectile dysfunction is acoustic wave therapy. This treatment (also known as shock wave therapy) involves the use of acoustic waves to cause neovascularization inside the penis. This is the formation of new blood vessels to promote erectile function (source).

This type of treatment has been in wide use in other fields like sports medicine for a long time and is gaining traction in the treatment of erectile dysfunction. I have personally used acoustic wave therapy to treat my erectile dysfunction with great success. With the help of these treatments, I no longer have any need for any oral ED medicine or for Trimix Injections.

TheMonsterSite has complete reviews of two major types of acoustic wave therapy for erectile dysfunction. The first type is the Gainswave system. Gainswave is a professionally administered type of acoustic wave therapy. It is very effective but it can be very costly. You can read the full review here.

The second type of acoustic wave therapy is the Phoenix device. This is an at-home system that can save you a lot of money over the in-office treatments. It is extremely effective and is the system that I currently use. You can read the full review here.


Alternatives for Penis Enlargement

While Trimix will not help to enlarge your penis, there are other alternatives out there. A major option is the surgical route such as suspensory ligament surgery. Other surgical and dermal filler options are available throughout the country. You can check our list of penis enlargement providers by state here.

I think that the most effective route for penis enlargement is the use of traction devices. Penis traction devices have the most scientific research behind them and are considered by many to be the most effective or only effective way to increase the length of the penis. The most important thing to remember about using traction devices to increase penis size is to find a quality device that can be worn safely and comfortably for hours at a time. You can read my complete review of penis traction devices including my personal results here.


Trimix is an incredibly effective erectile dysfunction medicine. When other medicines fail, Trimix is a great way to achieve an erection. Unfortunately, Trimix will not do anything to increase the size of your penis or improve your long-term erection quality. Fortunately, there are other ways to increase erection quality and penis size.

Related Posts

What Works for both Penis Lengthening and Thickening:

Penis Traction Devices Including Before and After Results

Top 5 Penis Traction Devices

Review of the Phallosan Forte for Penis Enlargement

Review of the Total Man System

What works for Erection Quality:

Review of The Phoenix Acoustic Wave Therapy Device for Erection Quality

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